Pompe disease is a rare hereditary disease characterized by the deficiency of an enzyme called acid alpha-glucosidase (GAA). One of the main features of Pompe disease is the progressive breakdown of communications between nerve and muscle cells. This image is of a leg muscle (tibialis anterior) from an adult mouse model of Pompe disease. Nerve cells (green) and cellular nerve-muscle communication sites, called neuromuscular junctions, (red) are fluorescently labeled to observe the continued deterioration of neuromuscular junctions. This research program has advanced the use of gene therapy to improve neural and cardiorespiratory function in patients with Pompe disease. This image won the 2015 Federation of American Societies for Experimental Biology (FASEB) BioArt competition.